Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 2.953


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX1chr10_+_1028810500.769.2e-04Click!
TLX3chr5_+_1706688920.058.6e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_45699830 9.651 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr22_+_40093245 8.556 NM_001145398
TEF
thyrotrophic embryonic factor
chr17_-_77394872 8.092 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr17_+_1580504 6.515 WDR81
WD repeat domain 81
chr17_+_74542066 6.470 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr16_-_30032330 6.257 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr2_-_217268492 6.198 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr12_-_54392328 6.190 NM_001144997
ITGA7
integrin, alpha 7
chr19_+_15612706 4.100 NM_000896
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr1_-_16217025 4.007 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr15_-_38420414 3.891 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr11_-_62213577 3.803 LRRN4CL
LRRN4 C-terminal like
chr8_-_22044463 3.754 NM_005144
NM_018411
HR

hairless homolog (mouse)

chrX_-_53327473 3.695 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr2_+_96818048 3.564 CNNM4
cyclin M4
chr7_-_16811131 3.531 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr12_-_50871953 3.457 NM_001081492
NM_182507
KRT80

keratin 80

chr9_+_35663852 3.448 NM_001216
CA9
carbonic anhydrase IX
chr17_-_74487527 3.407 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr9_+_139241838 3.386 NM_001190228
LOC643596
hypothetical LOC643596
chr20_-_60360789 3.379 LAMA5
laminin, alpha 5
chr5_+_38481392 3.328 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr5_+_150000394 3.318 NM_001109974
NM_007286
SYNPO

synaptopodin

chr11_-_62213946 3.253 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr3_+_8750485 3.092 NM_033337
NM_001234
CAV3

caveolin 3

chr17_+_75507750 3.085


chr11_-_85074848 3.083 NM_152723
CCDC89
coiled-coil domain containing 89
chr15_-_38417564 3.061 C15orf52
chromosome 15 open reading frame 52
chr9_+_130719034 3.019 LRRC8A
leucine rich repeat containing 8 family, member A
chr16_+_620932 3.002 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr17_-_24972471 2.941 NM_032854
CORO6
coronin 6
chr3_+_127743868 2.787 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr1_+_213245507 2.783 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr11_-_65082705 2.718 LTBP3
latent transforming growth factor beta binding protein 3
chr8_-_10550026 2.687 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr8_-_143864933 2.680 NM_003695
LY6D
lymphocyte antigen 6 complex, locus D
chr6_-_30151526 2.673 NM_170769
NM_025236
RNF39

ring finger protein 39

chr1_-_39180036 2.610 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr20_+_55569542 2.577 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr3_+_38007264 2.546 VILL
villin-like
chr3_-_11585264 2.545 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr16_+_2071631 2.538 TSC2
tuberous sclerosis 2
chr7_-_150283794 2.476 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr6_-_112001590 2.473 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr5_-_148738980 2.471 NM_014443
IL17B
interleukin 17B
chr15_-_32875040 2.461 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr19_+_40322231 2.442 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr11_-_10672079 2.421 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr17_+_72795567 2.384 NM_001113492
SEPT9
septin 9
chr1_+_33003814 2.363 NM_001198972
NM_001198973
KIAA1522

KIAA1522

chr20_-_5982617 2.362 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr12_+_123339662 2.359 NM_181709
FAM101A
family with sequence similarity 101, member A
chr1_-_16411690 2.348 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr12_-_120781002 2.332 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr14_-_80934523 2.295 NM_033104
STON2
stonin 2
chr6_+_39868770 2.285 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr1_-_6502655 2.188 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr11_+_74539679 2.140 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr1_+_33003847 2.134 KIAA1522
KIAA1522
chr11_+_77452550 2.077 NM_003251
THRSP
thyroid hormone responsive
chr9_-_131555111 2.053 NM_004878
PTGES
prostaglandin E synthase
chr21_+_39745649 2.053 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr6_-_31853027 2.051 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr18_+_41558089 1.987 NM_001128588
NM_001146036
NM_015865
SLC14A1


solute carrier family 14 (urea transporter), member 1 (Kidd blood group)


chr3_-_12175339 1.986 TIMP4
TIMP metallopeptidase inhibitor 4
chr1_-_245342150 1.986 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr1_-_159435440 1.983 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr11_-_10671736 1.963 MRVI1
murine retrovirus integration site 1 homolog
chr16_+_56219802 1.961 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr14_+_23937766 1.937 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr17_-_40348378 1.914 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr11_-_65082208 1.909 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr17_-_72045218 1.898 NM_134268
CYGB
cytoglobin
chr11_-_10671873 1.896 MRVI1
murine retrovirus integration site 1 homolog
chr20_-_33489383 1.893 NM_000557
GDF5
growth differentiation factor 5
chr21_+_32706615 1.843 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr9_+_135389698 1.821 NM_014694
ADAMTSL2
ADAMTS-like 2
chr1_-_151855413 1.808 NM_020672
S100A14
S100 calcium binding protein A14
chr9_-_78710698 1.807 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr15_-_66511488 1.773 NM_001004439
ITGA11
integrin, alpha 11
chr10_+_685887 1.763 C10orf108
chromosome 10 open reading frame 108
chr10_+_124310170 1.728 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr3_+_42675841 1.719 ZBTB47
zinc finger and BTB domain containing 47
chr1_-_149611768 1.706 NM_003944
SELENBP1
selenium binding protein 1
chr19_+_3659358 1.689 TJP3
tight junction protein 3 (zona occludens 3)
chr6_-_3390197 1.678 NM_021945
SLC22A23
solute carrier family 22, member 23
chr16_-_49742651 1.657 NM_002968
SALL1
sal-like 1 (Drosophila)
chr16_+_2025922 1.646 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr18_+_41558141 1.640 SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr8_-_13178327 1.614


chr4_+_86968069 1.576 ARHGAP24
Rho GTPase activating protein 24
chr9_+_123083540 1.574 GSN
gelsolin
chr5_-_54317102 1.571 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr6_-_28429950 1.569 NM_145909
ZNF323
zinc finger protein 323
chr1_-_27604656 1.525 WASF2
WAS protein family, member 2
chr5_+_121493113 1.505 NM_207317
ZNF474
zinc finger protein 474
chr17_-_39265965 1.503 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr1_-_151630168 1.495 NM_002964
S100A8
S100 calcium binding protein A8
chr22_+_31526801 1.495 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr1_+_159435728 1.473 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr20_-_43601542 1.466 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr1_-_218168548 1.457 NM_018713
SLC30A10
solute carrier family 30, member 10
chr17_-_36396778 1.450 NM_182497
KRT40
keratin 40
chr12_+_16397617 1.407 NM_145764
MGST1
microsomal glutathione S-transferase 1
chr1_+_1207351 1.395 NM_001130413
NM_002978
SCNN1D

sodium channel, nonvoltage-gated 1, delta

chr20_+_58004811 1.394 NM_021810
CDH26
cadherin 26
chrX_+_99785818 1.389 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr8_-_13018123 1.381 NM_001164271
DLC1
deleted in liver cancer 1
chr19_-_40696393 1.366 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr17_+_71065478 1.355 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr1_+_61319976 1.350 NM_001145512
NFIA
nuclear factor I/A
chr17_-_44226595 1.345 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr19_+_51493486 1.314 NM_022462
HIF3A
hypoxia inducible factor 3, alpha subunit
chr19_+_50004134 1.308 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr14_+_85066207 1.295 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr9_-_35860316 1.292 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr19_+_51498695 1.276 NM_152794
HIF3A
hypoxia inducible factor 3, alpha subunit
chr16_+_55963899 1.264 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr2_-_11727705 1.260 NM_012344
NTSR2
neurotensin receptor 2
chr8_+_22900863 1.245 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr9_+_138991835 1.236 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr19_-_4406285 1.215 NM_001171091
UBXN6
UBX domain protein 6
chr1_+_116181927 1.209 NHLH2
nescient helix loop helix 2
chr1_+_183970093 1.209 NM_031935
HMCN1
hemicentin 1
chr1_+_1836125 1.193 NM_138705
CALML6
calmodulin-like 6
chr9_-_23811842 1.179 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr9_-_112010233 1.176 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr3_-_12175646 1.171 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr22_+_19239221 1.170 MED15
mediator complex subunit 15
chr9_-_23811808 1.158 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr19_-_53950458 1.144 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr20_+_34206070 1.144 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr1_-_151852128 1.139 NM_080388
S100A16
S100 calcium binding protein A16
chr9_+_138991775 1.126 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr16_+_750765 1.122 NM_005823
NM_001177355
MSLN

mesothelin

chr14_+_94117545 1.121 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr1_-_32036802 1.118 SPOCD1
SPOC domain containing 1
chr8_-_22841173 1.117 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr1_-_227636462 1.110 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr14_+_22581215 1.108 NM_001099780
PSMB11
proteasome (prosome, macropain) subunit, beta type, 11
chrX_+_153423652 1.105 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr1_-_32036858 1.098 SPOCD1
SPOC domain containing 1
chr4_-_66218777 1.096 EPHA5
EPH receptor A5
chr1_+_158636987 1.095 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr11_-_102219450 1.090 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr16_-_28457825 1.088 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr7_+_1094248 1.086 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr2_+_223244606 1.084 NM_058165
MOGAT1
monoacylglycerol O-acyltransferase 1
chr16_+_23673448 1.069 NM_022097
CHP2
calcineurin B homologous protein 2
chr9_+_27099138 1.066 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr5_-_172130766 1.064 NM_004417
DUSP1
dual specificity phosphatase 1
chr19_-_360138 1.055 NM_001136263
C2CD4C
C2 calcium-dependent domain containing 4C
chr1_+_175407153 1.054 NM_021165
FAM5B
family with sequence similarity 5, member B
chr5_+_176449156 1.054 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr14_-_22515725 1.044 JUB
jub, ajuba homolog (Xenopus laevis)
chr7_+_150376537 1.043 NM_004769
NM_020321
NM_020322
ACCN3


amiloride-sensitive cation channel 3


chr12_-_8706637 1.043 NM_003480
MFAP5
microfibrillar associated protein 5
chr14_+_85066265 1.042 FLRT2
fibronectin leucine rich transmembrane protein 2
chrX_-_132947141 1.039 GPC3
glypican 3
chr10_+_88708267 1.029 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr2_+_85515428 1.021 NM_198482
SH2D6
SH2 domain containing 6
chr1_+_151867483 1.015 NM_006271
S100A1
S100 calcium binding protein A1
chr16_+_66476281 1.014 NM_198443
NRN1L
neuritin 1-like
chrX_+_2756810 1.004 NM_001079855
NM_001184702
NM_001184703
NM_001184704
NM_003918
GYG2




glycogenin 2




chr5_+_1254709 0.989 NM_001003841
SLC6A19
solute carrier family 6 (neutral amino acid transporter), member 19
chrX_+_122922058 0.982 NM_001042749
STAG2
stromal antigen 2
chr1_-_218168404 0.978


chr2_+_26924466 0.974 NM_020134
DPYSL5
dihydropyrimidinase-like 5
chr8_-_62764839 0.974 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr6_-_119512035 0.972 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr1_-_159325709 0.966 PVRL4
poliovirus receptor-related 4
chrX_+_46822751 0.958 RGN
regucalcin (senescence marker protein-30)
chr6_-_39305203 0.951 NM_003740
KCNK5
potassium channel, subfamily K, member 5
chr12_+_99391681 0.948 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr10_+_135010833 0.947 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr10_-_128067052 0.947 ADAM12
ADAM metallopeptidase domain 12
chr22_-_29290875 0.946 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr22_+_43451351 0.943 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr8_+_24828359 0.942 NM_001105541
NEFM
neurofilament, medium polypeptide
chr12_+_118100977 0.940 NM_014365
HSPB8
heat shock 22kDa protein 8
chr11_+_67532592 0.937 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr17_-_64462976 0.936 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chrX_-_132947290 0.936 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr10_+_80743769 0.927 ZMIZ1
zinc finger, MIZ-type containing 1
chr1_-_36338436 0.923 NM_005202
COL8A2
collagen, type VIII, alpha 2
chr1_-_203657803 0.921 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr4_+_183482130 0.921 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr9_+_6205804 0.919 IL33
interleukin 33
chr11_-_35397675 0.917 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_+_215884923 0.914 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chrX_+_106057984 0.905 CLDN2
claudin 2
chr10_-_128066935 0.904 ADAM12
ADAM metallopeptidase domain 12
chr1_-_27089354 0.903 GPN2
GPN-loop GTPase 2
chr5_-_59819642 0.901 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_52618815 0.901 NM_017410
HOXC13
homeobox C13
chr3_-_12561962 0.898 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr22_-_37970902 0.896 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr1_+_238321794 0.895 NM_020066
FMN2
formin 2
chr1_-_240679380 0.895 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr12_+_56406296 0.895 LOC100130776
hypothetical LOC100130776

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.07 3.33e-02 GO:0032535 regulation of cellular component size

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.68 6.54e-05 GO:0044421 extracellular region part
1.45 9.34e-05 GO:0005576 extracellular region
2.04 1.70e-03 GO:0031012 extracellular matrix
2.08 4.50e-03 GO:0005578 proteinaceous extracellular matrix

Nothing significant found in function category.